Argonaute 2 restored erectile function and corpus cavernosum mitochondrial function by reducing apoptosis in a mouse model of cavernous nerve injury.

Yan Huang Guo Nan Yin Fang-Yuan Liu Fitri Rahma Fridayana Lashkari Niloofar Minh Nhat Vo Ji Kan Ryu

Published in: Investigative and clinical urology (2024)

Our findings demonstrate that Ago2 overexpression can reduce penile cell apoptosis, restore penile mitochondrial function, and improve erectile function in CNI-induced ED mice.

Keyphrases

mouse model
cell proliferation
emergency department
oxidative stress
high glucose
diabetic rats
cell death
transcription factor
benign prostatic hyperplasia
prostate cancer
type diabetes
cell cycle arrest
high fat diet induced
metabolic syndrome
adipose tissue
endothelial cells
wild type