Patterns of Failure After Definitive Treatment of T4a Larynx Cancer.
Rohith S VooraBharat Akhanda PanugantiMitchell FlaggTyler NelsonNikhil V KothaEdmund M QiaoAlexander S QianAbhishek KumarTyler F StewartBrent S RoseJoseph A CalifanoPhilip A WeissbrodLoren K MellF Christopher HolsingerPublished in: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery (2021)
T4a LSCC survival discrepancies between surgical and nonsurgical treatment are influenced by varying recurrence behaviors. Surgery was associated with superior disease control and improved survival. Beyond the known benefit in locoregional control with surgery, there may be a protective effect on distant recurrence that depends on regional disease burden.