CXCL12-induced neurotoxicity critically depends on NMDA receptor-gated and L-type Ca2+ channels upstream of p38 MAPK.

Ana B SanchezKathryn E MeddersRicky MaungPaloma Sánchez-PavónDaniel Ojeda-JuárezMarcus Kaul

Published in: Journal of neuroinflammation (2016)

Our findings link CXCL12-induced neuronal death to the regulation of NMDAR-gated ion channels and L-type Ca2+ channels upstream of p38 MAPK activation.

Keyphrases

high glucose
diabetic rats
drug induced
oxidative stress
brain injury
blood brain barrier