Accumulation of Circulating Cell-Free CpG-Enriched Ribosomal DNA Fragments on the Background of High Endonuclease Activity of Blood Plasma in Schizophrenic Patients.
E S ErshovaE M JestkovaA V MartynovGalina V ShmarinaPavel E UmriukhinL V BravveN V ZakharovaG P KostyukD V SavelievM D OrlovaM BogushS I KutsevN N VeikoSvetlana V KostyukPublished in: International journal of genomics (2019)
Despite the abnormally high endonuclease activity in the blood plasma of SZ patients, the circulating cfDNA concentration is increased. Fragments of cf-rDNA accumulate in the blood plasma of SZ patients. Potentially, SZ patients' cfDNA should be a strong stimulating factor for the TLR9-MyD88-NF-κB signaling pathway.