Human Papillomavirus E7 and p16 INK4a mRNA Multiplexed Quantification by a QuantiGene TM Proof-of-Concept Assay Sensitively Detects Infection and Cervical Dysplasia Severity.

Anna Sophie SkofLina RotenbergPaul Viktor Felix HannemannSarah ThiesEleonora Boschetti-GrützmacherAndreas Martin Kaufmann

Published in: Diagnostics (Basel, Switzerland) (2023)

transcripts when normalized to ACTB is informative about the presence of cervical dysplasia and potentially discriminates between low-grade and high-grade dysplasia and invasive cervical cancer. Further studies including more HPV genotypes and biomarkers are warranted.

Keyphrases

high grade
low grade
high throughput
single cell
case control