Genomic Characteristics and Single-Cell Profiles After Immunotherapy in Fumarate Hydratase-Deficient Renal Cell Carcinoma.

Pei Dong Xinyue Zhang Yu-Lu Peng Yijun Zhang Ruiqi Liu Yilin Li Qiwen Pan Wen-Su Wei Sheng-Jie Guo Zhiling Zhang Hui Han Fang-Jian Zhou Yang Liu Liru He

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

Immune infiltration is frequent in FHRCC. ICI-based treatment is a promising regimen, and treatment response depends on the functional status of tumor-infiltrating lymphocytes. ICI-based treatment cannot reverse the exhaustion of CD8+ T cells in patients with progressive disease, highlighting the need for additional therapeutic strategies.

Keyphrases

single cell
renal cell carcinoma
multiple sclerosis
gene expression
copy number