A flow equilibrium of zinc in cells of Cupriavidus metallidurans .
Dietrich H NiesGrit SchleuderDiana GaleaMartin HerzbergPublished in: Journal of bacteriology (2024)
Understanding the biochemical action of a single enzyme or transport protein is the pre-requisite to obtain insight into its cellular function but this is only one half of the coin. The other side concerns the question of how central metabolic functions of a cell emerge from the interplay of different proteins and other macromolecules. This paper demonstrates that a flow equilibrium of zinc uptake and efflux reactions is at the core of cellular zinc homeostasis and identifies the most important contributors to this flow equilibrium: the uptake and efflux systems and metal-binding components of the cytoplasm.
Keyphrases
- molecular dynamics
- oxide nanoparticles
- molecular dynamics simulations
- induced apoptosis
- single cell
- cell cycle arrest
- cell therapy
- aqueous solution
- genome wide
- binding protein
- gene expression
- signaling pathway
- dna methylation
- protein protein
- small molecule
- cell death
- cell proliferation
- transcription factor
- mesenchymal stem cells
- bone marrow
- amino acid
- dna binding