Overexpression of HMGB1 in hepatocytes accelerates PTEN inactivation-induced liver cancer.

Dipti Athavale Inés Barahona Zhuo-Lun Song Romain Desert Hong You Hui Han Sukanta Das Xiaodong Ge Sai Santosh Babu KomakulaShenglan GaoDaniel LantvitGrace GuzmanNatalia Nieto

Published in: Hepatology communications (2023)

Overexpression of HMGB1 in hepatocytes accelerates liver tumorigenesis in Pten∆Hep mice, enhancing cell proliferation and F4/80+ cells to drive MASH-induced liver cancer.

Keyphrases

cell proliferation
high glucose
pi k akt
drug induced
diabetic rats
liver injury
cell cycle
induced apoptosis
type diabetes
oxidative stress
endothelial cells
signaling pathway
adipose tissue
high fat diet induced
cell death
insulin resistance