Proteome Analysis of Pancreatic Tumors Implicates Extracellular Matrix in Patient Outcome.

Laxmi Silwal-PanditStina M StålbergHenrik J JohanssonGeorgios MermelekasInger Marie B LotheMartina L SkredeAstrid Marie DalsgaardDaniel J H Nebdal Åslaug Helland Ole Christian Lingjærde Knut Jørgen LaboriBjørn S SkålheggJanne LehtiöElin H Kure

Published in: Cancer research communications (2022)

Pancreatic cancer lacks reliable biomarkers for prognostication and treatment of patients. We analyzed the proteome of pancreatic tumors, nonmalignant tissues of the pancreas and PDX-derived cell lines, and identified proteins that discriminate between patients with good and poor survival. The proteomics data also unraveled potential novel drug targets.

Keyphrases

extracellular matrix
mass spectrometry
gene expression
case report
electronic health record
big data
risk assessment
free survival
label free
adverse drug
climate change