Hepatocytes reprogram liver macrophages involving control of TGF-β activation, influencing liver regeneration and injury.
Stephanie D WolfChristian EhltingSophia Müller-DottGereon PoschmannPatrick PetzschTobias LautweinSai WangBarbara HelmMarcel SchillingJulio Saez-RodriguezMihael VucurKai StühlerKarl KöhrerFrank TackeSteven DooleyUrsula KlingmüllerTom LueddeJohannes Georg BodePublished in: Hepatology communications (2023)
The availability of activated TGF-β determines the activation state of specific macrophage populations in the liver, and the observed rapid transient activation of TGF-β may represent an important regulatory mechanism in the early phase of liver regeneration in this context.