Mast Cell Activation in the Systemic Sclerosis Esophagus.

Kevin TomBhaven K MehtaAileen HoffmannKathleen ArenMary CarnsJungwha LeeViktor MartyanovDillon PopovichNoelle KosarekTammara WoodDarren BrennerDustin A CarlsonLorena OstillaEmma WillcocksPaul BryceJoshua B WechslerMichael L WhitfieldMonique E Hinchcliff

Published in: Journal of scleroderma and related disorders (2020)

Esophageal mast cell numbers are heterogeneous in SSc patients and may correlate with acid exposure. Patients with inflammatory IS profiles in the esophagus demonstrate more tryptase staining. Mast cell targeted therapy may be a useful therapeutic approach in SSc patients belonging to the inflammatory IS, but additional studies are warranted.

Keyphrases

systemic sclerosis
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
oxidative stress
peritoneal dialysis
interstitial lung disease
patient reported