Diesel engine exhaust accelerates plaque formation in a mouse model of Alzheimer's disease.
Maja HullmannCatrin AlbrechtDamiën van BerloMiriam E Gerlofs-NijlandTina WahleAgnes W BootsJean KrutmannFlemming R CasseeThomas A BayerRoel P F SchinsPublished in: Particle and fibre toxicology (2017)
Inhalation exposure to DEE causes accelerated plaque formation and motor function impairment in 5XFAD transgenic mice. Our study provides further support that the brain is a relevant target for the effects of inhaled DEE and suggests that long-term exposure to this ubiquitous air pollution mixture may promote the development of Alzheimer's disease.