Modulation of Sirt1-mTORC1 Pathway in Microglia Attenuates Retinal Ganglion Cell Loss After Optic Nerve Injury.

Qianxue MouKe YaoMeng YeBowen ZhaoYuanyuan HuXiaotong LouHuixia LiHong ZhangYin Zhao

Published in: Journal of inflammation research (2021)

Our study reveals a potential novel mechanism of SIRT1-mTORC1 pathway in microglia regulation, and indicates a therapeutic potential for the protection of RGCs in ONI.

Keyphrases

optic nerve
inflammatory response
oxidative stress
neuropathic pain
ischemia reperfusion injury
optical coherence tomography
single cell
cell therapy
stem cells
risk assessment
spinal cord
human health
spinal cord injury
mesenchymal stem cells
bone marrow