Myeloproliferative Neoplasms Transcriptome Reveals Pro-Inflammatory Signature and Enrichment in Peripheral Blood Monocyte-Related Genes.
Vitor Leonardo BassanRafaela de Freitas Martins FelícioKelen Cristina Ribeiro MalmegrimFabíola Attié de CastroPublished in: Cancer investigation (2024)
Myeloproliferative neoplasms (MPN) are hematological diseases associated with genetic driver mutations in the JAK2, CALR, and MPL genes and exacerbated oncoinflammatory status . Analyzing public microarray data from polycythemia vera (n = 41), essential thrombocythemia (n = 21), and primary myelofibrosis (n = 9) patients' peripheral blood by in silico approaches, we found that pro-inflammatory and monocyte-related genes were differentially expressed in MPN patients' transcriptome. Genes related to cell activation, secretion of pro-inflammatory and pro-angiogenic mediators, activation of neutrophils and platelets, coagulation, and interferon pathway were upregulated in monocytes compared to controls. Together, our results suggest that molecular alterations in monocytes may contribute to oncoinflammation in MPN.
Keyphrases
- peripheral blood
- genome wide
- end stage renal disease
- dendritic cells
- ejection fraction
- newly diagnosed
- chronic kidney disease
- single cell
- healthcare
- gene expression
- prognostic factors
- endothelial cells
- rna seq
- mental health
- dna methylation
- stem cells
- patient reported outcomes
- bone marrow
- machine learning
- artificial intelligence
- copy number
- electronic health record
- single molecule
- data analysis
- bioinformatics analysis