Adverse Pregnancy Outcomes among HIV-infected Women Taking Isoniazid Preventive Therapy During the First Trimester.

Amita GuptaMichael D HughesJorge Leon CruzAnchalee AvihingsanonNoluthando MwelasePatrice SevereAyotunde Omoz-OarheGaerolwe MashetoLaura MoranConstance A BensonRichard E ChaissonSusan Swindells

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2023)

First-trimester IPT exposure was associated with nearly two-fold increased risk of fetal demise, mostly spontaneous abortion, though the association was attenuated when adjusted for covariates proximal to pregnancy outcome including ART use. Further study is needed to inform TB prevention guidelines.

Keyphrases

pregnancy outcomes
hiv infected
pregnant women
mycobacterium tuberculosis
antiretroviral therapy
human immunodeficiency virus
clinical practice
stem cells
polycystic ovary syndrome
metabolic syndrome
type diabetes
preterm birth
smoking cessation
adverse drug
electronic health record
breast cancer risk