PRC2 is required for extensive reorganization of H3K27me3 during epigenetic reprogramming in mouse fetal germ cells.

Lexie ProkopukJessica M StringerKirsten HoggKirstin D ElgassPatrick S Western

Published in: Epigenetics & chromatin (2017)

Combined, these data reveal a role for Polycomb Repressive Complex 2 and trimethylated lysine 27 on histone 3 during germline epigenetic programming that we speculate is required to repress target sequences while DNA methylation is removed.

Keyphrases

dna methylation
genome wide
gene expression
induced apoptosis
cell cycle arrest
electronic health record
copy number
dna repair
single cell
endoplasmic reticulum stress
big data
oxidative stress
machine learning
data analysis
dna damage
deep learning
amino acid