Diagnosis of primary central nervous system lymphoma: a systematic review of the utility of CSF screening and the role of early brain biopsy.

Alexis A MorellAshish H ShahClaudio CavalloDaniel G EichbergChristopher A SarkissRonald BenvenisteMichael E IvanRicardo J Komotar

Published in: Neuro-oncology practice (2019)

The diagnostic yield of CSF analyses for PCNSL in immunocompetent patients remains exceedingly low. Our institutional series demonstrates that early biopsy for PCNSL is safe and accurate, and may avert protracted work-ups. We conclude that performing an early brain biopsy in a suspected case of PCNSL is a valid, safe option to minimize diagnostic delay.

Keyphrases

ultrasound guided
end stage renal disease
fine needle aspiration
resting state
white matter
ejection fraction
chronic kidney disease
newly diagnosed
cerebrospinal fluid
functional connectivity
peritoneal dialysis
high resolution
patient reported outcomes
multiple sclerosis