A novel device and system concept for therapeutic plasma exchange in rats.

Mitica Ciorpac Cezar-Cătălin CaratașuAndrei SzilagyiCosmin Teodor Mihai Ionuţ Nistor Radu Iliescu Bogdan Ionel Tamba

Published in: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy (2023)

The TPE unit for rats was able to produce 95% plasma exchange rate in non-anesthetized animals, enabling a full translation of the human TPE into an animal model. The newly developed plasmapheresis unit enable a wide range of more accurate preclinical evaluation, with cardiac parameters monitoring, using small rodents in awaken state.

Keyphrases

endothelial cells
left ventricular
high resolution
induced pluripotent stem cells
stem cells
heart failure
mass spectrometry
atrial fibrillation