Zingiber officinale Rosc. in the Treatment of Metabolic Syndrome Disorders-A Review of In Vivo Studies.
Ewelina GumbarewiczAgata JarząbAndrzej StepulakWirginia Kukuła-KochPublished in: International journal of molecular sciences (2022)
Inflammation is a protective reaction of the innate immune system as a response to imbalances caused by a specific stimulus, a disease or a pathogen. A prolonged inflammatory condition may lead to the development of metabolic syndrome, which affects more than one-fourth of the world's population. This condition leads to the development of multi-organ disorders based on disrupted blood lipid and sugar levels, hypertension and oxidative stress. The review aims to present Zingiber officinale Rosc. as a plant that exhibits a variety of healing properties and restores the organism's equilibrium. Ginger (GI) rhizomes have been commonly used in traditional medicine to treat arthritis, stomach ache, nonalcoholic fatty liver disease, rheumatism, nervous system syndromes, asthma, diabetes and nausea caused by pregnancy or chemotherapy. This review gathers together data from in vivo experiments related to the application of ginger for the treatment of inflammatory conditions, obesity, diabetes and other related disorders as a consequence of metabolic syndrome, including the confirmed molecular mechanisms of action.
Keyphrases
- metabolic syndrome
- oxidative stress
- insulin resistance
- type diabetes
- cardiovascular disease
- uric acid
- immune response
- cardiovascular risk factors
- blood pressure
- rheumatoid arthritis
- chronic obstructive pulmonary disease
- dna damage
- glycemic control
- skeletal muscle
- combination therapy
- molecular dynamics
- ischemia reperfusion injury
- pregnant women
- chemotherapy induced
- replacement therapy
- plant growth
- heat shock protein
- drug induced