Pharmacokinetic Variability of Rufinamide and Stiripentol in Children with Refractory Epilepsy: A Retrospective Study of Therapeutic Drug Monitoring from the National Epilepsy Centers in Denmark and Norway.

Katrine HegerMargrete Larsen BurnsMarina NikanorovaSvein I JohannessenCecilie Johannessen Landmark

Published in: Therapeutic drug monitoring (2024)

This study demonstrates considerable pharmacokinetic variability in and between patients for both drugs and similar use in terms of age, burden of comedication and retention rates. TDM may be useful in the clinical setting to monitor and optimize treatment in this vulnerable patient group.

Keyphrases

end stage renal disease
newly diagnosed
chronic kidney disease
ejection fraction
young adults
risk factors
drug induced
replacement therapy
patient reported