Colchicine enhances β adrenoceptor-mediated vasodilation in men with essential hypertension.
Thomas S EhlersJennifer van der HorstSophie MøllerPeter K PiilLasse GliemannChristian AalkjaerThomas A JeppsYlva HellstenPublished in: British journal of clinical pharmacology (2023)
Colchicine acutely enhances β adrenoceptor- and NO-mediated changes in vascular conductance in humans, supporting that the mechanism previously demonstrated in rodents, translates to humans. The results provide novel translational evidence for a transient enhancing effect of colchicine on β adrenoceptor-mediated vasodilation in humans with essential hypertension.
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