Gut Microbiota-Derived Butyrate Induces Epigenetic and Metabolic Reprogramming in Myeloid-Derived Suppressor Cells to Alleviate Primary Biliary Cholangitis.

Rui WangBo LiBingyuan HuangYikang LiQiaoyan LiuZhuwan LyuRuiling ChenQiwei QianXueying LiangXiting PuYi WuYu ChenQi MiaoQixia WangMin LianXiao XiaoPatrick S C LeungM Eric GershwinZhengrui YouXiong MaRuqi Tang

Published in: Gastroenterology (2024)

We identify a critical role for butyrate in modulation of MDSC homeostasis by orchestrating epigenetic and metabolic crosstalk, proposing a novel therapeutic strategy for treating PBC.

Keyphrases

dna methylation
induced apoptosis
gene expression
cell cycle arrest
endoplasmic reticulum stress
cell proliferation