STING promotes homeostatic maintenance of tissues and confers longevity with aging.
Jacob W HopkinsKatherine B SulkaMachlan SawdenKimberly A CarrollRonald D BrownStephen C BunnellAlexander PoltorakAlbert TaiEric R ReedShruti SharmaPublished in: bioRxiv : the preprint server for biology (2024)
fingerprints, primarily driven by interactions of tissue stromal and myeloid populations. STING shapes these immune fingerprints of aging tissues in unexpected ways.Loss of STING alters the location, numbers, and viability of tissue resident macrophages.STING signaling is critical for longer lifespans and maintenance of tissue architecture.