Non-invasive biomarkers derived from the extracellular matrix associate with response to immune checkpoint blockade (anti-CTLA-4) in metastatic melanoma patients.

Christina JensenDaniel Hargbøl MadsenMorten HansenHenrik SchmidtInge Marie SvaneMorten Asser KarsdalNicholas Willumsen

Published in: Journal for immunotherapy of cancer (2018)

ECM and tissue remodeling quantified in pre-treatment serum were associated with response and survival outcomes in metastatic melanoma patients treated with IPI. This highlights the importance of addressing the ECM and stromal component non-invasively in future ICI studies.

Keyphrases

extracellular matrix
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
bone marrow
patient reported outcomes
case control