Declining trends of reoperations and disease behavior progression in Crohn's disease over different therapeutic eras - a prospective population-based study from western Hungary between 1977-2020, data from the Veszprem cohort.

We report a continuous decline in reoperation rates and disease behavior progression in CD over time with the lowest values in the biological era. In contrast, there was no further decrease in the probability of first major resective surgery after the immunosuppressive era.