The Alzheimer's disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130.
Stephan A MüllerMerav D ShmueliXiao FengJohanna TüshausNeele SchumacherRyan ClarkBrad E SmithAn ChiStefan Rose-JohnMatthew E KennedyStefan F LichtenthalerPublished in: Molecular neurodegeneration (2023)
BACE1 is a new modulator of gp130 function. The BACE1-cleaved, soluble gp130 may serve as a pharmacodynamic BACE1 activity marker to reduce the occurrence of side effects of chronic BACE1 inhibition in humans.