Reactive non-sexually related acute genital ulcers associated with COVID-19.
Jill M KrapfRachel K CaseyAndrew T GoldsteinPublished in: BMJ case reports (2021)
Acute genital ulcers (AGU), known as Lipschütz ulcers, are painful vulvar ulcers typically affecting non-sexually active girls and women. AGU have been associated with viral infections, namely, Epstein-Barr virus (EBV). Here, we describe a case of AGU in the setting of SARS-CoV-2 in a non-sexually active adolescent girl hospitalised for pain control and urinary retention, who failed a course of oral corticosteroids and then improved with colchicine. Testing for herpes simplex virus, EBV and Behcet's syndrome were all negative. Testing for SARS-CoV-2 was positive. COVID-19 increases cytokines such as tumour necrosis factor alpha, which has been shown to affect endothelial cell adhesion and neutrophil chemotaxis, leading to aphthosis.
Keyphrases
- sars cov
- epstein barr virus
- diffuse large b cell lymphoma
- liver failure
- respiratory syndrome coronavirus
- cell adhesion
- herpes simplex virus
- respiratory failure
- drug induced
- wound healing
- coronavirus disease
- aortic dissection
- chronic pain
- young adults
- endothelial cells
- mental health
- pain management
- polycystic ovary syndrome
- type diabetes
- radiation therapy
- pregnant women
- intensive care unit
- metabolic syndrome
- spinal cord injury
- hepatitis b virus
- mechanical ventilation
- adipose tissue
- acute respiratory distress syndrome
- spinal cord
- pregnancy outcomes
- breast cancer risk
- cervical cancer screening