APOL1 in an ethnically diverse pediatric population with nephrotic syndrome: implications in focal segmental glomerulosclerosis and other diagnoses.
Andreia WatanabeMara Sanches GuaragnaVera Maria Santoro BelangeroFernanda Maria Casimiro da FonsecaJoão Bosco PesqueroLuciana de Santis FeltranLilian Monteiro Pereira PalmaPatrícia VarelaPrecil Diego Miranda de Menezes NevesAntonio Marcondes LerarioMarcela Lopes de SouzaMaricilda Palandi de MelloAnna Cristina Gervásio de Brito LutaifCassio Rodrigues FerrariMatthew Gordon SampsonLuiz Fernando OnuchicPaulo Cesar Koch NogueiraPublished in: Pediatric nephrology (Berlin, Germany) (2021)
Novel discoveries include a substantial prevalence of HRG among patients self-reported White, worse kidney outcomes in HRG versus LRG children in the FSGS subgroup, and a trend of higher CKD progression risk associated with a single risk variant in the SRNS cohort. These findings suggest APOL1-associated NS extends beyond patients self-reported non-White, the HRG effect is independent of FSGS, and a single risk variant may have a detrimental impact in children with NS.