CCM3 Loss-Induced Lymphatic Defect Is Mediated by the Augmented VEGFR3-ERK1/2 Signaling.
Lingfeng QinHaifeng ZhangBusu LiQuan JiangFrancesc LopezWang MinJenny Huanjiao ZhouPublished in: Arteriosclerosis, thrombosis, and vascular biology (2021)
Our data demonstrate that CCM3 deletion augments the VEGFR3-ERK1/2 signaling in lymphatic EC that drives lymphatic hyperplasia and malformation and warrant further investigation on the potential clinical relevance of lymphatic dysfunction in patients with CCM.