Euphocactoside, a New Megastigmane Glycoside from Euphorbia cactus Growing in Saudi Arabia.
Hanan Y AatiShagufta PerveenJawaher Al-QahtaniJiangnan PengAreej Al-TaweelAli S AlqahtaniAli ElGamalGiuseppina ChianeseFahd A NasrTaglialatela-Scafati OrazioMohammad K ParvezPublished in: Plants (Basel, Switzerland) (2022)
A phytochemical investigation of the aerial parts of Euphorbia cactus Ehrenb. ex Boiss. revealed a new megastigmane, euphocactoside ( 5 ), along with eleven known metabolites. Euphocactoside ( 5 ) is the 3- O -glucoside derivative of a polyhydroxylated megastigmane showing unprecedented structural features. The structure of euphocactoside, including stereochemical details, was elucidated by extensive spectroscopic analysis based on 1D and 2D nuclear magnetic resonance (NMR) and high-resolution mass spectrometry (HR-ESIMS). The isolated compounds were evaluated for their cytotoxic activity against three different human cancer cell lines, namely, A549 (lung), LoVo (colon), and MCF-7 (breast), using MTT assay, and moderate to marginal activities were observed for compounds 1 - 3 , 8 and 9 against all three cell lines.
Keyphrases
- magnetic resonance
- high resolution mass spectrometry
- liquid chromatography
- endothelial cells
- papillary thyroid
- ultra high performance liquid chromatography
- molecular docking
- gas chromatography
- mass spectrometry
- squamous cell
- high resolution
- ms ms
- high throughput
- single cell
- breast cancer cells
- high intensity
- squamous cell carcinoma
- magnetic resonance imaging
- solid state
- molecular dynamics simulations
- solid phase extraction