Modelling idiopathic intracranial hypertension in rats: contributions of high fat diet and testosterone to intracranial pressure and cerebrospinal fluid production.
Jonathan H WardmanMette N JensenSøren N AndreassenBjarne StyrishaveJens E WilhjelmAlexandra Jean SinclairNanna MacAulayPublished in: Fluids and barriers of the CNS (2023)
HFD-induced ICP elevation in experimental rats occurred with decreased CSF drainage capacity. Adjuvant testosterone, mimicking the androgen excess observed in female IIH patients, elevated the CSF secretion rate and thus ICP. Obesity-induced androgen dysregulation may thus contribute to the disease mechanism of IIH.
Keyphrases
- high fat diet
- insulin resistance
- cerebrospinal fluid
- high glucose
- adipose tissue
- diabetic rats
- end stage renal disease
- blood pressure
- newly diagnosed
- metabolic syndrome
- ejection fraction
- chronic kidney disease
- replacement therapy
- prognostic factors
- type diabetes
- skeletal muscle
- peritoneal dialysis
- weight loss
- patient reported outcomes
- oxidative stress
- endothelial cells
- weight gain
- physical activity