Drosophila models of PIGA-CDG mirror patient phenotypes.
Holly J ThorpeKatie G OwingsMiriam C AzizMadelyn HallerEmily CoelhoClement Y ChowPublished in: bioRxiv : the preprint server for biology (2023)
PIGA-CDG is a rare genetic disorder. In order to study this rare disease, we generated and characterized several Drosophila models of PIGA-CDG. These models faithfully recapitulate different patient phenotypes, including movement disorder and seizures. Drosophila is a good model for PIGA-CDG and other GPI anchor disorders.