Antagonizing EZH2 combined with vitamin D3 exerts a synergistic role in anti-fibrosis through bidirectional effects on hepatocytes and HSCs.
Qinghui ZhangRongrong JiaMinjie ChenJianjun WangFeng HuangMin ShiHuiming ShengLing XuPublished in: Journal of gastroenterology and hepatology (2023)
Vitamin D3 is responsible for the anti-fibrosis, which might have bidirectional effects on HSCs by regulating histone modification. The inhibitor of Ezh2 plays a synergistic role in this process.