Heparan sulfate chains contribute to the anticoagulant milieu in malignant pleural effusion.

Emilia HardakEli PeledYonatan CrispelShourouk GhanemJudith AttiasKeren AsayagInna KoganYona Nadir

Published in: Thorax (2019)

HS chains released by heparanase form an anticoagulant milieu in MPE, preventing local thrombosis and enabling tumour cell proliferation. Inhibition of heparanase might provide a therapeutic option for patients with recurrent MPE.

Keyphrases

cell proliferation
atrial fibrillation
venous thromboembolism
pulmonary embolism
cell cycle
pi k akt