Clinical Application of Adenovirus (AdV): A Comprehensive Review.
Md SalauddinSukumar SahaMd Golzar HossainKenji OkudaMasaru ShimadaPublished in: Viruses (2024)
Adenoviruses are non-enveloped DNA viruses that cause a wide range of symptoms, from mild infections to life-threatening diseases in a broad range of hosts. Due to the unique characteristics of these viruses, they have also become a vehicle for gene-transfer and cancer therapeutic instruments. Adenovirus vectors can be used in gene therapy by modifying wild-type viruses to render them replication-defective. This makes it possible to swap out particular viral genes for segments that carry therapeutic genes and to employ the resultant vector as a means of delivering genes to specified tissues. In this review, we outline the progressive development of adenovirus vectors, exploring their characteristics, genetic modifications, and range of uses in clinical and preclinical settings. A significant emphasis is placed on their crucial role in advancing gene therapy, cancer therapy, immunotherapy, and the latest breakthroughs in vaccine development for various diseases.
Keyphrases
- gene therapy
- genome wide
- genome wide identification
- cancer therapy
- wild type
- bioinformatics analysis
- dna methylation
- genome wide analysis
- copy number
- gene expression
- multiple sclerosis
- sars cov
- drug delivery
- papillary thyroid
- transcription factor
- squamous cell carcinoma
- stem cells
- depressive symptoms
- mesenchymal stem cells
- genetic diversity
- lymph node metastasis
- patient reported outcomes