Porcine placenta extract improves high-glucose-induced angiogenesis impairment.

Chatchai NensatWorawat SongjangRutaiwan TohtongTuangporn SuthiphongchaiSuchada PhimsenPanthip RattanasinganchanPornphimon MetheenukulSarawut KumphuneArunya Jiraviriyakul

Published in: BMC complementary medicine and therapies (2021)

PPE attenuated HG-induced intracellular ROS overproduction that improved ECs viability, proliferation, migration, and angiogenesis by showing recovery of PI3K/Akt/ERK1/2 activation and inhibition of ECs apoptosis. This study suggests PPE ameliorated HG-induced ROS-mediated angiogenesis impairment, whereby it potentially provides an alternative treatment for diabetic wounds.

Keyphrases

high glucose
endothelial cells
pi k akt
signaling pathway
diabetic rats
cell cycle arrest
cell death
vascular endothelial growth factor
oxidative stress
dna damage
type diabetes
drug induced
fluorescent probe
living cells
single molecule
combination therapy