Radiation-induced cystic brain necrosis developing 10 years after linac-based stereotactic radiosurgery for brain metastasis.
Rihito AizawaMegumi UtoKeiichi TakehanaYoshiki ArakawaSusumu MiyamotoTakashi MizowakiPublished in: Oxford medical case reports (2018)
Cystic brain necrosis (CBN) is a rare form of BN. It typically occurs as a very late complication, and no standard treatment has been established. We report a case of a 59-year-old man who developed CBN 10 years after radiation therapy for metastatic brain tumors. The therapy consisted of whole brain radiotherapy followed by linac-based stereotactic radiosurgery as a boost. Initially, the CBN continued to expand despite treatment with corticosteroids and bevacizumab. Therefore, we resected the tumor and implanted an Ommaya reservoir, which successfully stabilized the lesion. Although the prognosis of patients with brain metastases is generally poor, some patients, like the one reported here, achieve long survival. Therefore, we should follow such cases carefully, considering the possibility of developing CBN as a late complication.
Keyphrases
- radiation induced
- resting state
- white matter
- small cell lung cancer
- brain metastases
- functional connectivity
- radiation therapy
- end stage renal disease
- squamous cell carcinoma
- cerebral ischemia
- chronic kidney disease
- ejection fraction
- stem cells
- early stage
- mesenchymal stem cells
- locally advanced
- subarachnoid hemorrhage
- metastatic colorectal cancer
- rectal cancer
- cell therapy
- smoking cessation
- replacement therapy