Minor Nortriterpenoids from the Twigs and Leaves of Rhododendron latoucheae.
Fei LiuYa-Nan WangYong LiShuang-Gang MaJing QuYun-Bao LiuChang-Shan NiuZhong-Hai TangYu-Huan LiLi LiShi-Shan YuPublished in: Journal of natural products (2018)
A hyphenated NMR technique (analytical HPLC with a DAD connected to MS, SPE, and NMR) has proven effective for the full structural analysis and identification of minor natural products in complex mixtures. Application of this hyphenated technique to the CH2Cl2-soluble fraction of Rhododendron latoucheae led to the identification of 15 new minor ursane-type 28-nortriterpenoids (1-15). Compounds 1 and 12 inhibited HSV-1 with IC50 values of 6.4 and 0.4 μM, respectively.
Keyphrases
- ms ms
- magnetic resonance
- high resolution
- simultaneous determination
- solid state
- mass spectrometry
- high resolution mass spectrometry
- liquid chromatography
- bioinformatics analysis
- multiple sclerosis
- solid phase extraction
- ionic liquid
- room temperature
- high performance liquid chromatography
- tandem mass spectrometry
- light emitting