Biopsychosocial distress and clinical outcome in metastatic renal cell carcinoma.
Cristiane Decat BergerotKaren Lynn ClarkKimlin Tam AshingPaulo Gustavo BergerotRichard ObenchainNazli DizmanJoAnn HsuErrol PhilipMatthew LoscalzoSumanta Kumar PalPublished in: Palliative & supportive care (2018)
A cohort of 102 patients with mRCC treated at a single institution was assessed by a touch screen-based instrument comprising 22 core items spanning physical, practical, functional, and emotional domains. Association between biopsychosocial distress and clinicopathologic criteria was interrogated. Overall survival was compared between patients with low distress versus high distress.ResultHigh rates of distress (20.7%) were found among patients newly diagnosed with mRCC. Among those domains contributing to distress, pain, fatigue, and financial comorbidity were the most commonly reported by patients with mRCC. A trend toward poorer overall survival in those patients with high distress versus low distress was observed among mRCC patients.Significance of resultsBased on data from a relatively large sample of patients, this study provides the first specific insights into the potential impact of biopsychosocial distress and outcomes among patients with mRCC.
Keyphrases
- newly diagnosed
- end stage renal disease
- ejection fraction
- chronic kidney disease
- physical activity
- chronic pain
- healthcare
- high throughput
- type diabetes
- patient reported outcomes
- metastatic renal cell carcinoma
- spinal cord
- neuropathic pain
- big data
- skeletal muscle
- single cell
- health insurance
- data analysis
- human health
- glycemic control
- artificial intelligence