miR-4510 blocks hepatocellular carcinoma development through RAF1 targeting and RAS/RAF/MEK/ERK signalling inactivation.
Amani GhouseinNicola MoscaFlora CartierJustine CharpentierJean-William DupuyAnne Aurélie RaymondPaulette Bioulac-SageChristophe F GrossetPublished in: Liver international : official journal of the International Association for the Study of the Liver (2019)
In this work, we confirm that RAF1 acts as an oncogene in HCC and further demonstrate that miR-4510 acts as a strong tumour suppressor in the liver by targeting many proto-oncogenes, including GPC3 and RAF1, and subsequently controlling key biological and signalling pathways among which Wnt and RAS/RAF/MEK/ERK signals.