Association of Reproductive History With Brain MRI Biomarkers of Dementia Risk in Midlife.

Eva SchelbaumLacey LoughlinSteven JettCenai ZhangGrace JangNiharika MalviyaHollie HristovSilky PahlajaniRichard IsaacsonJonathan P DykeHooman KamelRoberta Diaz BrintonLisa Mosconi

Published in: Neurology (2021)

Reproductive history events signaling more estrogen exposure such as premenopausal status, longer reproductive span, higher number of children, and use of HT and HC were associated with larger GMV in women in midlife. Further studies are needed to elucidate sex-specific biological pathways through which reproductive history influences cognitive aging and AD risk.

Keyphrases

young adults
mild cognitive impairment
polycystic ovary syndrome
breast cancer risk
white matter
contrast enhanced
postmenopausal women
cognitive impairment
computed tomography
magnetic resonance
resting state
adipose tissue
pregnant women
pregnancy outcomes