Harmonizing Healthy Cohorts to Support Multicenter Studies on Migraine Classification using Brain MRI Data.

The harmonization method was established by Healthy Core Construction.The inclusion of a healthy core addresses intrinsic heterogeneity that exists within a healthy control cohort and in multicenter studies.The utilization of a healthy core can increase the accuracy and generalizability of brain imaging-based classification models.The proposed harmonization method offers flexible utilities for multicenter studies.