Oncogenic role of microRNA-155 in mycosis fungoides: an in vitro and xenograft mouse model study.
L MoyalS YehezkelB GorovitzA KerenA GilharI LubinS ShermanE HodakPublished in: The British journal of dermatology (2017)
Oncogenic miR-155 appears to contribute to the cancerous phenotype of MyLa and MJ cells, but not of Hut78 cells, by interrupting activation of the G2/M checkpoint in response to SL111, and decreasing apoptosis in response to SL111 and SAHA, thereby facilitating tumour growth. These findings have implications for the potential development of novel therapeutic modalities for MF incorporating miR-155 inhibitors.