Design of a fluorogenic PNA probe capable of simultaneous recognition of 3'-overhang and double-stranded sequences of small interfering RNAs.

Takaaki TanabeTakaya SatoYusuke Sato Seiichi Nishizawa

Published in: RSC advances (2018)

We developed a new fluorescent peptide nucleic acid (PNA) probe, COT probe, capable of simultaneous recognition of 3'-overhang and double stranded sequences of target small interfering RNA (siRNA).

Keyphrases

nucleic acid
living cells
quantum dots
fluorescent probe
single molecule
cancer therapy
binding protein
genetic diversity
label free