TNFα induces Caspase-3 activity in hematopoietic progenitor cells CD34+, CD33+, and CD41 + of myelodysplastic syndromes.

Anggraini Iriani Andhika RachmanRahayuningsih D SetiabudySiti B KresnoAru W SudoyoMansyur AriefAlida R HarahapMarsya Kaila Fatina

Published in: BMC molecular and cell biology (2023)

rhTNFα exposure led to an elevation in caspase-3 activity in MDS progenitor cells, especially in those that had differentiated into myeloid cell CD33 + and megakaryocyte cell CD41+, as opposed to the early progenitor cells CD34+.

Keyphrases

cell death
nk cells
bone marrow
rheumatoid arthritis
dendritic cells
stem cells
induced apoptosis
signaling pathway
oxidative stress