Elevated platelet-leukocyte complexes are associated with, but dispensable for myocardial ischemia-reperfusion injury.

Christopher StarzCarmen HärdtnerMaximilian MaulerBianca DufnerNatalie HoppeKatja KrebsCarolin Anna EhlertJulian MerzTimo HeidtPeter StachonDennis WolfChristoph BodeConstantin von Zur MuehlenWolfgang RottbauerMeinrad GawazDaniel DuerschmiedFlorian LeuschnerOliver BorstDirk WestermannIngo Hilgendorf

Published in: Basic research in cardiology (2022)

We conclude that myocardial infarction associated sterile inflammation triggers PLC formation, reminiscent of conserved immunothrombotic responses, but without PLC influencing myocardial ischemia and reperfusion injury in return. Our experimental data do not support a therapeutic concept of selectively targeting PLC formation in myocardial infarction.

Keyphrases

left ventricular
ischemia reperfusion injury
oxidative stress
acute myocardial infarction
heart failure
cerebral ischemia
transcription factor
electronic health record
cancer therapy
big data
acute ischemic stroke
machine learning
brain injury
acute coronary syndrome