Twenty-four Month Outcomes in the Collaborative Ocular Tuberculosis Study (COTS)-1: Defining the "Cure" in Ocular Tuberculosis.
Aniruddha Kishandutt AgarwalRupesh V AgrawalDhananjay RajeIlaria TestiSarakshi MahajanDinesh Visva GunasekeranKanika AggarwalSomasheila I MurthyMark WestcottSoon-Phaik CheePeter MccluskeySu Ling HoStephen TeohCimino LucaJyotirmay BiswasShishir NarainManisha AgarwalPadmamalini MahendradasMoncef KhairallahNicholas JonesCarl P HerbortKalpana BabuSoumayava BasuEster CarreñoRichard LeeHassan Al-DhibiBahram BodaghiAlessandro InvernizziDebra A GoldsteinCarl P HerbortTalin Barisani-AsenbauerJulio José González-LópezSofia AndroudiReema BansalBruttendu MoharanaSimona Degli EspostiAnastasia TasiopoulouSengal NadarajahMamta AgarwalSharanya AbrahamRuchi ValaRamandeep SinghAman SharmaKusum SharmaManfred ZierhutOnn Min KonEmmett T CunninghamJohn H KempenQuan Dong NguyenCarlos PavesioVishali GuptaPublished in: Ocular immunology and inflammation (2020)
Majority of subjects (>75%) achieved cure in the COTS-1 at 24-month follow-up. The concept of "cure" may be a valuable clinical endpoint in trials for OTB.