Mesenchymal stromal/stem cells modulate response to experimental sepsis-induced lung injury via regulation of miR-27a-5p in recipient mice.
Nadim YounesLouis ZhouHajera AmatullahShirley H J MeiRaquel HerreroJose Angel LorenteDuncan J StewartPhilip MarsdenW Conrad LilesPingzhao HuClaudia C Dos SantosPublished in: Thorax (2020)
Our data support involvement of miR-27a-5p and VAV3 in cellular adhesion and infiltration during acute lung injury and a potential role for miR-27a-based therapeutics for acute respiratory distress syndrome.
Keyphrases
- acute respiratory distress syndrome
- stem cells
- extracorporeal membrane oxygenation
- mechanical ventilation
- bone marrow
- cell proliferation
- long non coding rna
- high glucose
- lipopolysaccharide induced
- intensive care unit
- lps induced
- diabetic rats
- acute kidney injury
- long noncoding rna
- small molecule
- high fat diet induced
- cell therapy
- big data
- endothelial cells
- type diabetes
- biofilm formation
- drug induced
- cell migration
- oxidative stress
- staphylococcus aureus
- deep learning
- candida albicans
- mesenchymal stem cells
- skeletal muscle
- cell adhesion