Non-invasive imaging of mouse embryo metabolism in response to induced hypoxia.

Emily A SeidlerT SanchezM VenturasD SakkasD J Needleman

Published in: Journal of assisted reproduction and genetics (2020)

Quantitative FLIM-based metabolic imaging was highly sensitive to metabolic changes induced by hypoxia. Metabolic response profiles to oxygen deprivation were distinct at different stages, reflecting differences in metabolic plasticity as preimplantation embryos develop.

Keyphrases

high resolution
endothelial cells
high glucose
oxidative stress
mass spectrometry
fluorescence imaging
living cells
molecularly imprinted