The Platelet Lipidome Is Altered in Patients with COVID-19 and Correlates with Platelet Reactivity.
Alex R SchuurmanValentine LéopoldLiza PereverzevaOsoul ChouchaneTom D Y ReijndersJustin de BrabanderRenée A DoumaMichel van WeeghelEric WeverBauke V SchomakerFrédéric M VazWillem Joost WiersingaCornelis Van't VeerTom van der PollPublished in: Thrombosis and haemostasis (2022)
Taken together, this investigation provides the first exploration of the profound impact of infection on the human platelet lipidome, and reveals associations between the lipid composition of platelets and their reactivity. These results warrant further lipidomic research in other infections and disease states involving platelet pathophysiology.